“Intraoperative Radiation Therapy (IORT) is a radiation treatment that is administered during surgery. It allows delivery of radiation directly to the target area for cancers that are difficult to remove during surgery or in situations in which there may be microscopic amounts of cancer remaining after removal. IORT delivers higher doses of radiation than can be used in conventional radiation therapy because the doctor can temporarily move nearby organs or shield them from radiation exposure.
IORT is often combined with conventional radiation therapy which is typically given prior to surgery.
A BRIEF HISTORY OF TARGETED INTRA-OPERATIVE RADIOTHERAPY:
“The first generation of IORT accelerators were usually developed in-house on basis of commercial radiotherapy accelerators, in cooperation with the manufacturers.
The in-house developments have been almost completely replaced by specialized small mobile IORT accelerators. At present, three commercial IORT linear accelerators (linacs) are available on the market. They are designed as mobile devices in order to be installed in an existing operation room without the need of reconstructions for wall mounting. They allow moving the accelerator to the patient and not vice versa and can so avoid transport of the surgically opened patient.”
STAGES IN THE DEVELOPMENT OF TARGETED INTRA-OPERATIVE RADIOTHERAPY:
PIONEERS IN THE DEVELOPMENT OF TARGETED INTRA-OPERATIVE RADIOTHERAPY:
REFERENCES:
https://ro-journal.biomedcentral.com/articles/10.1186/s13014-016-0754-z
https://www1.radmd.com/media/714379/iort-radonc-2018.pdf
https://www.jayantvaidya.org/breast_cancer_surgeon/TARGIT_files/shapeimage_2.png
https://www.bmj.com/content/370/bmj.m2836
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61950-9/fulltext